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An illustration of the pain signaling pathway elicited by CGRP. CGRP activates the CGPR receptor on Schwann cells. The CGPR receptor traffics to endosomes, where sustained signaling ends in the release of nitric oxide.Diabetic neuropathy represents a singular intersection of your “basic” hemodynamic outcomes of Ang II signaling and its far more… Read More

The vasogenic principle dominated the discussion of migraine pathogenesis until nineteen eighties. Sir Harold Wolff,14 The nice clinician of his time, noticed a few key areas: a) extracerebral vessels dilate through the migraine assault and are agonizing; b) cranial blood vessel stimulation provokes an ipsilateral headache; c) vasoconstrictor drugs… Read More

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